Article ID Journal Published Year Pages File Type
10762049 Biochemical and Biophysical Research Communications 2012 6 Pages PDF
Abstract
► Sorafenib down-regulates c-IAP1 protein levels in vitro and in vivo. ► Sorafenib does not impact mRNA synthesis or protein stability of c-IAP1. ► Sorafenib suppresses c-IAP1 translation by targeting the IRES. ► Over-expression of c-IAP1 antagonizes sorafenib induced apoptosis in cancer cells.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Sorafenib down-regulates c-IAP expression post-transcriptionally in hepatic carcinoma cells to suppress apoptosis
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