Article ID Journal Published Year Pages File Type
10762085 Biochemical and Biophysical Research Communications 2012 6 Pages PDF
Abstract
► We tested the hypothesis that low concentrations of flavonoids inhibit NF-κB in astrocytes. ► Primary cultured astrocytes possess a functional κB-system, measured using luciferase assays. ► Seven flavonoids (100 nM-1 μM) failed to reduce NF-κB activity in astrocytes. ► Four flavonoids (100 nM-1 μM) failed to reduce TNFa-stimulated NF-κB activity in astrocytes. ► (−)-Epicatechin did not regulate nuclear translocation of the NF-κB subunit, p65.
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