Article ID Journal Published Year Pages File Type
10762110 Biochemical and Biophysical Research Communications 2012 6 Pages PDF
Abstract
► We produced a neutralizing antibody against clade 1 of H5 influenza virus. ► The antibody recognized the loop at amino acid positions 140-145 of HA1. ► The amino acids at 142, 144, and 145 were critical for the antibody recognition. ► The antibody cross-neutralized the clade 2.2.1 but not clade 2.1.3.2 or 2.3.4 of H5 virus. ► The amino acids at 142 and 145 were conserved in the clade 2.2.1 virus.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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