| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762113 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Nicotine induces E-selectin gene through the E2F1 transcription factor. ⺠Inhibiting E2F1 activity prevents nicotine-induced E-selectin expression. ⺠E2F1 activity was needed for nicotine-induced adhesion of monocytes to HAECs. ⺠Targeting the Rb-E2F pathway might be an avenue to combat atherosclerosis.
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Authors
Vignesh Alamanda, Sandeep Singh, Nicholas J. Lawrence, Srikumar P. Chellappan,