| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762119 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Hybrid liposomes (HLs) consist of vesicular and micellar molecules. ⺠HLs inhibit the growth of cancer cells but not normal cells to trigger apoptosis. ⺠HLs selectively fuse and accumulate into the membranes of cancer cells. ⺠Cancer cell-membranes are more fluid than normal cell-membranes. ⺠HLs target cancer cell-membranes that have higher fluidity to trigger apoptosis.
Keywords
BCNUl-α-dimyristoylphosphatidylcholinefifty percent inhibitory concentrationPBS (−)WST-1DPHTIRFDDSdMPCTween 20HLSIC501,6-diphenyl-1,3,5-hexatrieneHCCApoptosisMembrane fluidityDrug delivery systemphosphate buffered-salinefluorescence polarizationHybrid liposomesHepatocellular carcinomatotal internal reflection fluorescence
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Authors
Yuji Komizu, Hidetsugu Ueoka, Ryuichi Ueoka,