| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762148 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠We constructed the pharmacophore model for hERG channel facilitation. ⺠This model consists of one positively ionizable feature and three hydrophobic features. ⺠The spatial distribution of these features are different from that of blockers. ⺠Facilitation could be induced by a different mechanism.
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Authors
Yuko Yamakawa, Kazuharu Furutani, Atsushi Inanobe, Yuko Ohno, Yoshihisa Kurachi,