| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762163 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Stem Cell Technologies Aggrewells⢠were surface modified by applying layers of Chitosan and Hyaluronic acid. ⺠Surface modification resulted in superior aggregate formation, even in serum containing medium. ⺠3D MSC osteogenesis outperformed conventional 2D monolayer cultures. ⺠BMP-2 was significantly upregulated in 3D MSC microaggregates regardless of media composition. ⺠Increased BMP-2 autocrine signalling in 3D microaggregates appears to enhance MSC osteogenesis.
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Authors
Mahboubeh Kabiri, Betul Kul, William B. Lott, Kathryn Futrega, Parisa Ghanavi, Zee Upton, Michael R. Doran,