Induction of mitochondrial uncoupling enhances VEGF120 but reduces MCP-1 release in mature 3T3-L1 adipocytes: Possible regulatory mechanism through endogenous ER stress and AMPK-related pathways

Article ID	Journal	Published Year	Pages	File Type
10762177	Biochemical and Biophysical Research Communications	2012	6 Pages	PDF

Abstract

âº Mitochondrial uncoupling was induced by treatment with metabolic uncoupler, DNP. âº DNP significantly augmented CHOP contents and AMPK activity in 3T3-L1 adipocytes. âº DNP significantly decreased MCP-1 release in 3T3-L1 adipocytes. âº DNP reduced MCP-1 release via induction of ER stress and by activation of AMPK. âº JNK phosphorylation in 3T3-L1 adipocytes was decreased by treatment with DNP.

Keywords

MCP-1 Adipocytes uncoupling Vascular Endothelial Growth Factor (VEGF)Mitochondria

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Preview

Induction of mitochondrial uncoupling enhances VEGF120 but reduces MCP-1 release in mature 3T3-L1 adipocytes: Possible regulatory mechanism through endogenous ER stress and AMPK-related pathways

Authors

Kaoru Miyokawa-Gorin, Kazuto Takahashi, Keiko Handa, Atsuko Kitahara, Yoshikazu Sumitani, Hidenori Katsuta, Toshiaki Tanaka, Susumu Nishida, Katsuhiko Yoshimoto, Hideki Ohno, Hitoshi Ishida,