Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10762180 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠BM- and Ad-MSCs produce high amounts of PGE2 in the presence of activated T-cells. ⺠The elicitation of the PGE2 secretion of MSCs is contact-dependent. ⺠TNF-α and IFN-γ act synergistically to induce PGE2 production. ⺠L-NMA could only partially inhibit PGE2 secretion in response to TNF-α and IFN-γ. ⺠The PGE2 secretion of MSCs is not mediated by a unique molecular mechanism.
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Authors
Beáta Hegyi, Gyöngyi Kudlik, Ãva Monostori, Ferenc Uher,