Article ID Journal Published Year Pages File Type
10762253 Biochemical and Biophysical Research Communications 2012 7 Pages PDF
Abstract
► CBP sequence is identified from BSP and has collagen binding activity. ► CBP directly activates the MAPK signaling, especially ERK1/2. ► CBP increase osteoblastic differentiation by the activation of Runx2. ► CBP decrease adipogenic differentiation by the inhibition of PPARγ.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Determination of osteogenic or adipogenic lineages in muscle-derived stem cells (MDSCs) by a collagen-binding peptide (CBP) derived from bone sialoprotein (BSP)
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