| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762260 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠ROS decreases during hypoxia, but increases during reoxygenation in MDA-MB-231 cells. ⺠Thioredoxin protein levels are increased during reoxygenation following hypoxia. ⺠Pre-conditioning with hypoxia and reoxygenation upregulates thioredoxin and Ref-1. ⺠High thioredoxin cell surface levels occur after reoxygenation and pre-conditioning. ⺠The thioredoxin gene promoter is activated during reoxygenation by Nrf-2.
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Authors
Therese C. Karlenius, Fenil Shah, Giovanna Di Trapani, Frank M. Clarke, Kathryn F. Tonissen,