Article ID Journal Published Year Pages File Type
10762293 Biochemical and Biophysical Research Communications 2012 7 Pages PDF
Abstract
► CXCL9 is a biased agonist on CXCR3. ► CXCR3 signaling can be detected using label-free impedance technology. ► CXCR3-induced impedance changes are mediated via Gαi-proteins. ► Impedance measurements reveal differences in signaling kinetics of various ligands. ► Impedance measurements reveal CXCR3-independent responses by CXCL9 and VUF10661.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with Gi-protein pathway activation
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