| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762303 | Biochemical and Biophysical Research Communications | 2012 | 5 Pages |
Abstract
⺠Multi-cellular Ca2+ transient duration was obtained in left ventricular slices. ⺠Isoproterenol-induced cardiac hypertrophy showed down-regulation of SERCA2a protein. ⺠Shortened Ca2+ transient duration suggests up-regulation of SERCA2a activity. ⺠A novel NHE-1 selective inhibitor normalized shortened Ca2+ transient duration. ⺠Normalization of SECA2a activity may contribute.
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Authors
Hiroshi Hattori, Daisuke Takeshita, Ayako Takeuchi, Bongju Kim, Munetaka Shibata, Satoshi Matsuoka, Koji Obata, Shinichi Mitsuyama, Guo-Xing Zhang, Miyako Takaki,