| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762326 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠Insig-1 is markedly degraded in spinal cords of G93A tg mice and ALS patients. ⺠Spinal cord degradation of Insig-1 is associated with SREBP1 activation in G93A mice and human ALS. ⺠Mouse spinal neuron excitotoxicity is blocked by SREBP1 peptide inhibitor Indip.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Changiz Taghibiglou, Jie Lu, Ian R. Mackenzie, Yu Tian Wang, Neil R. Cashman,