The transcription factor FOXM1c is activated by protein kinase CK2, protein kinase A (PKA), c-Src and Raf-1

Article ID	Journal	Published Year	Pages	File Type
10762344	Biochemical and Biophysical Research Communications	2011	6 Pages	PDF

Abstract

âº The auto-inhibitory N-terminus of FOXM1c inhibits the transactivation domain of FOXM1c. âº Protein kinase CK2 activates FOXM1c by releasing FOXM1c from the inhibition by its N-terminus. âº Protein kinase A (PKA) activates FOXM1c by releasing FOXM1c from the inhibition by its N-terminus. âº c-Src activates FOXM1c by relieving the repression of FOXM1c by its auto-inhibitory N-terminus. âº Raf-1 activates FOXM1c independently of the auto-inhibitory N-terminus of FOXM1c.

Keywords

CDK DBD ERK CK2, protein kinase CK2 cAMP cyclic adenosine 3′,5′-monophosphate DNA binding domain dominant-negative casein kinase II extracellular signal-regulated kinase cyclin-dependent kinase