RNA polymerase II degradation in response to rapamycin is not mediated through ubiquitylation

Article ID	Journal	Published Year	Pages	File Type
10762348	Biochemical and Biophysical Research Communications	2011	6 Pages	PDF

Abstract

âº RNAPII is degraded in response to rapamycin requiring the Tor1 signaling pathway. âº The peptidyl prolyl isomerase Rrd1 is required for this process. âº Degradation of RNAPII is independent of its ubiquitylation. âº Rrd1 mediates the degradation through a novel mechanism.

Keywords

CTD 4-NQO RNAPII RNA polymerase II 4-nitroquinoline-1-oxide C-terminal domain Rapamycin target of rapamycin Ubiquitylation peptidyl prolyl isomerase

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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RNA polymerase II degradation in response to rapamycin is not mediated through ubiquitylation

Authors

Nathalie Jouvet, Jeremie Poschmann, Julie Douville, Rim Marrakchi, Dindial Ramotar,