Article ID Journal Published Year Pages File Type
10762351 Biochemical and Biophysical Research Communications 2011 5 Pages PDF
Abstract
► We found that a natural product, Sanguinarine, directly bound and activated AMPK. ► Sanguinarine showed unique isotype selectivity in its activation effect. ► The allosteric mechanism of Sanguinarine was distinct from that of the natural ligand, AMP. ► A docking study predicts that Sanguinarine binds at the cleft between the beta and gamma subunits.
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