| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762381 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠Sulfated LMWLs are novel allosteric inhibitors of human thrombin. ⺠Site-directed thrombin mutants were used to identify the site of binding of sulfated LMWLs. ⺠Arg93 and Arg175 were found to be key residues for recognizing sulfated LMWLs. ⺠The identification of this novel allosteric site on thrombin will greatly assist the design of new anticoagulants.
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Authors
May H. Abdel Aziz, Philip D. Mosier, Umesh R. Desai,