| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762391 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠We investigate cellular effects of novel procaspase-3 activators PAC-1 and 1541. ⺠PAC-1 and 1541 induce cell death in PC12 cells and primary neurons. ⺠EGF completely blocks PAC-1 induced caspase-3 activity. ⺠EGF can reduce cell death induced by PAC-1 and 1541. ⺠Relevant for further development of procaspase-3 activators for cancer therapy.
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Authors
Karen A. Boldingh Debernard, Gulzeb Aziz, Annine Thomassen Gjesvik, Ragnhild E. Paulsen,