| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762413 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠ppGalNAc-T13 was up-regulated in high metastatic sublines of Lewis lung cancer. ⺠ppGalNAc-T13 expression enhanced cell invasion activity in low metastatic sublines. ⺠Trimeric Tn antigen was induced in the transfectant cells of ppGalNAc-T13 cDNA. ⺠A major protein carrying trimeric Tn structure was identified as Syndecan-1. ⺠Silencing of ppGalNAc-T13 resulted in the reduction of invasion and of metastasis..
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Authors
Yasuyuki Matsumoto, Qing Zhang, Kaoru Akita, Hiroshi Nakada, Kazunori Hamamura, Noriyo Tokuda, Akiko Tsuchida, Takeshi Matsubara, Tomoko Hori, Tetsuya Okajima, Keiko Furukawa, Takeshi Urano, Koichi Furukawa,