| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762422 | Biochemical and Biophysical Research Communications | 2012 | 5 Pages |
Abstract
⺠Aβ42 expression induces apoptosis and reduces survival and locomotion in Drosophila. ⺠Inhibition of JNK signaling or caspases suppresses the Aβ42-induced impairments. ⺠Aβ42-induced cell death and neurological phenotypes are dependent on the dFOXO level. ⺠Oral uptake of the JNK inhibitor rescues the impairments of Aβ42-expressing flies. ⺠JNK/dFOXO signaling is a major pathway mediating the impairments of the fly AD model.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Yoon Ki Hong, Soojin Lee, Seung Hwan Park, Jang Ho Lee, Seung Yeop Han, Sang Tae Kim, Young-Kyoon Kim, Songhee Jeon, Byung-Soo Koo, Kyoung Sang Cho,