| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762486 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠The amino acid transporter SLC6A19 is upregulated by Janus kinase-2 JAK2. ⺠The V617FJAK2 mutant, causing myeloproliferative disease, is more effective. ⺠JAK2 inhibitor AG490 reverses stimulation of SLC6A19 by V617FJAK2. ⺠JAK2 enhances SLC6A19 protein insertion into the cell membrane. ⺠SLC6A19 may contribute to amino acid uptake into V617FJAK2 expressing tumor cells.
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Authors
Shefalee K. Bhavsar, Zohreh Hosseinzadeh, Katja Merches, Shuchen Gu, Stefan Bröer, Florian Lang,