Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1Î² secretion

Article ID	Journal	Published Year	Pages	File Type
10762512	Biochemical and Biophysical Research Communications	2011	6 Pages	PDF

Abstract

âº EGCG inhibits melanoma cell growth at physiological doses (0.1-1Â Î¼M). âº EGCG inhibits melanoma cell growth via inflammasomes and IL-1Î² suppression. âº Inflammasomes and IL-1Î² could be potential targets for future melanoma therapeutics.

Keywords

Epigallocatechin-3-gallate NLRP1 Nlrp nucleotide oligomerization domain NLR NOD EGCG shRNA ASC IL-1 short hairpin RNA Inflammasome interleukin Melanoma caspase recruitment domain apoptosis-associated speck-like protein containing a CARD Green tea CARD Nod-like receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1Î² secretion

Authors

Lixia Z. Ellis, Weimin Liu, Yuchun Luo, Miyako Okamoto, Dovina Qu, Jeffrey H. Dunn, Mayumi Fujita,