| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762514 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Both klotho mRNA spliceforms are regulated by 1,25-dihydroxyvitamin D (1,25D). ⺠Regulation occurs in cell lines from kidney proximal, distal and collecting tubules. ⺠Candidate vitamin D response elements (VDREs) found near mouse and human kl genes. ⺠Two human VDREs and one mouse VDRE are active in reporter gene assays. ⺠Klotho regulation by 1,25D may potentiate phosphaturic effect of FGF23.
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Authors
Ryan E. Forster, Peter W. Jurutka, Jui-Cheng Hsieh, Carol A. Haussler, Christine L. Lowmiller, Ichiro Kaneko, Mark R. Haussler, G. Kerr Whitfield,