Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10762566 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠Proteasome inhibitors stabilized mutant GAA in patient cells with c.546G>T mutation. ⺠Proteasome inhibitors promoted the maturation of mutant GAA in patient cells. ⺠Proteasome inhibitors restored subcellular localization of patient GAA to lysosome. ⺠Proteasome inhibitors increased the GAA enzyme activity in patient cells.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Yohta Shimada, Hikaru Nishida, Yurika Nishiyama, Hiroshi Kobayashi, Takashi Higuchi, Yoshikatsu Eto, Hiroyuki Ida, Toya Ohashi,