Multimerisation of A disintegrin and metalloprotease protein-17 (ADAM17) is mediated by its EGF-like domain

Article ID	Journal	Published Year	Pages	File Type
10762609	Biochemical and Biophysical Research Communications	2011	7 Pages	PDF

Abstract

âº The transmembrane protease ADAM17 is a multimer. âº Formation of ADAM17 multimers is independent of its transmembrane- and cytoplasmic- region. âº Multimerisation is solely mediated by its EGF-like domain.

Keywords

TNFα MEF GPi ADAM17 IL-6R EGF-like domain Metzincins Multimerisation A disintegrin and metalloprotease 17 tumor necrosis factor α cysteine-rich domain Dimer Metalloprotease mouse embryonic fibroblasts glycosylphosphatidylinositol Interleukin-6 receptor