Article ID Journal Published Year Pages File Type
10762622 Biochemical and Biophysical Research Communications 2011 7 Pages PDF
Abstract
► RhoE is transcriptionally up-regulated during hypoxia in gastric cancer cells. ► RhoE up-regulation is associated with HIF-1α induction. ► HIF-1 binds to the RhoE promoter. ► Hypoxia promotes EMT and invasion in gastric cancer cells. ► The hypoxia-induced EMT phenotype is mediated by HIF-1α and RhoE.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Transcriptional up-regulation of RhoE by hypoxia-inducible factor (HIF)-1 promotes epithelial to mesenchymal transition of gastric cancer cells during hypoxia
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