The plant limonoid 7-oxo-deacetoxygedunin inhibits RANKL-induced osteoclastogenesis by suppressing activation of the NF-ÎºB and MAPK pathways

Article ID	Journal	Published Year	Pages	File Type
10762633	Biochemical and Biophysical Research Communications	2011	6 Pages	PDF

Abstract

âº A gedunin type limonoid from seeds of mangroves, 7-oxo-7-deacetoxygedunin, exhibits strong anti-osteoclastogenic activity. âº Treatment with this limonoid results in significant decrease in expression of NFATc1 and osteoclast-related genes. âº The mode of action of this limonoid is by inhibiting activation of the NF-ÎºB and MAPK pathways which are activated by RANKL.

Keywords

RANKL qRT-PCR TRAP M-CSF quantitative RT-PCR Osteoclast MAPK pathway NF-κB pathway receptor activator of NF-κB ligand