| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762636 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠HIF pathway plays vital role in neovascularization in cancer and retinal diseases. ⺠Hypoxia induces expression of histone lysine demethylases (KDMs) in a retinal cell. ⺠The expression of pro-angiogenic genes is dependent on KDMs under hypoxic conditions. ⺠Treating cells with a KDM inhibitor blocks the expression of pro-angiogenic genes. ⺠Specific inhibitors of KDMs can be used to treat hypoxia induced neovascularization.
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Authors
V.K. Chaithanya Ponnaluri, Ramya Krishna Vadlapatla, Divya Teja Vavilala, Dhananjay Pal, Ashim K. Mitra, Mridul Mukherji,