| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762649 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1 are histone methyltransferases linked to numerous cancers. ⺠Little is known about the NSD pathways and HMTase inhibitors are sorely needed in the epigenetic therapy of cancers. ⺠We investigate the regulation and the recognition of histone marks by the SET domain of NSD1. ⺠A unique and key mechanism is driven by a loop at the interface of the SET and postSET region. ⺠Implications for developing specific and selective HMTase inhibitors are presented.
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Authors
Masayo Morishita, Eric di Luccio,