| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762663 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Substrate recognition by UDP-GalNAc 4-epimerases is analyzed using sitedirected mutants. ⺠Most of the single point mutants retain the activity similar to the wild-type enzyme. ⺠Structure of the His305Ala mutant suggests the substrate-binding site to be fairly elastic. ⺠Graded loss in activity occurs as the mutations causing loss in hydrogen bonds accumulate.
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Authors
Veer Sandeep Bhatt, Wanyi Guan, Mengyang Xue, Huiqing Yuan, Peng George Wang,