| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762674 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠Inhibiting Î9 desaturase drastically changes T. brucei's fatty-acid composition. ⺠Isoxyl specifically inhibits the Î9 desaturase causing a growth arrest. ⺠RNA interference of desaturase expression causes a similar effect. ⺠Feeding T. brucei-infected mice with Isoxyl decreases the parasitemia. ⺠70% of Isoxyl-treated mice survived the trypanosome infection.
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Authors
Andrés Alloatti, Shreedhara Gupta, Melisa Gualdrón-López, Paul A. Nguewa, Silvia G. Altabe, Gladys Deumer, Pierre Wallemacq, Paul A.M. Michels, Antonio D. Uttaro,