| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762680 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠In this study we have demonstrated that FLT3 activation leads to activation of ERK5. ⺠We have demonstrated that ERK5 is involved in activation of AKT downstream of FLT3. ⺠BIX02188 blocks activation of ERK5 and induces apoptosis in FLT3 Ba/F3 cells. ⺠BIX02188 induce apoptosis in the two leukemic cell lines MV4-11 and MOLM-13.
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Authors
Elena Razumovskaya, Jianmin Sun, Lars Rönnstrand,