Protein kinase Cη activates NF-κB in response to camptothecin-induced DNA damage

► Protein kinase C-eta (PKCη) is an upstream regulator of the NF-κB signaling pathway. ► PKCη activates NF-κB in non-stressed conditions and in response to DNA damage. ► PKCη regulates NF-κB by activating IκB kinase (IKK) and inducing IκB degradation.