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Critical role of type 1 plasminogen activator inhibitor (PAI-1) in early host defense against nontypeable Haemophilus influenzae (NTHi) infection

Article ID Journal Published Year Pages File Type
10762728 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► PAI-1 expression is induced by NTHi in lung tissues of mice. ► Early induction of PAI-1 is critical for anti-microbial defense against NTHi. ► NTHi induces PAI-1 via activation of TLR2-MyD88-MKK3-p38 MAPK signaling pathway.
Keywords
Nontypeable Haemophilus influenzaeinflammationPneumoniaType 1 plasminogen activator inhibitorInnate immune response
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Critical role of type 1 plasminogen activator inhibitor (PAI-1) in early host defense against nontypeable Haemophilus influenzae (NTHi) infection
Authors
Jae Hyang Lim, Chang-Hoon Woo, Jian-Dong Li,
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Biochemical and Biophysical Research Communications
Journal: Biochemical and Biophysical Research Communications
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