| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762731 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Thyroid hormone effects in two model breast cancer cells were monitored. ⺠Thyroid hormone induces mitochondrial metabolism and mitochondrial biogenesis. ⺠These effects depend on the degree of Warburg phenotype displayed by the cells. ⺠Thyroid hormone sensitizes mitochondria in aggressive cancer cells to chemotherapeutic agents.
Keywords
GLUT-1pyruvate kinase M2 isoformtetramethyl rhodamine methyl esterPhosphatidylinositol 3-KinasesPKM2TMRMPGC-1DCFDAPEPPI3KCCD5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate, acetyl esterROSWarburg effectTriiodothyroninethyroxineCharge-Coupled DeviceBioenergeticsBreast cancerChemotherapyphosphoenol pyruvateMitochondriaNADHThyroid hormonehexokinaseReactive oxygen species
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Authors
Sonal Suhane, V. Krishnan Ramanujan,