| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762732 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠Crocetin inhibited fibril formation of beta-amyloid (Aβ). ⺠Crocetin destabilized pre-formed Aβ fibrils. ⺠Crocetin caused stabilization of Aβ oligomers. ⺠Crocetin prevented conversion of Aβ oligomers into Aβ fibrils.
Keywords
hexafluoroisopropanolPBSASDSHFIPOligomerMALDI-TOFEDTAβHSA1,2-EthanedithiolDMSOtris(2-carboxyethyl)phosphinehuman serum albuminmatrix-assisted laser desorption/ionization time-of-flight mass spectrometryTemBeta-amyloidThTAlzheimer’s diseaseprotein aggregationThioflavin TDimethyl sulfoxidecircular dichroismTCEPBBBBlood–brain barriersodium dodecyl sulfateFibrilTransmission electron microscopyCrocetinhigh-performance liquid chromatographyHPLC
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Authors
Joon Ho Ahn, Yang Hu, Michael Hernandez, Jin Ryoun Kim,