| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762733 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Linkage specific changes in fucosylation have been associated with cancer. ⺠The Aleuria aurantia lectin (AAL) can bind fucose but has limited linkage specificity. ⺠Through site-directed mutagenesis we developed AALs with altered binding affinities. ⺠These AAL molecules could be used to determine fucose changes in cancer.
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Authors
Patrick R. Romano, Andrew Mackay, Minh Vong, Johann deSa, Anne Lamontagne, Mary Ann Comunale, Julie Hafner, Timothy Block, Ryszard Lec, Anand Mehta,