| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762753 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Inhibiting eEF-2 kinase sensitizes human glioma cells to TRAIL therapy. ⺠The enhanced sensitivity to TRAIL is accompanied by down-regulation of Bcl-xL. ⺠Overexpression of Bcl-xL can abrogate this sensitizing effect on TRAIL. ⺠Targeting eEF-2 kinase may represent a new adjuvant therapy with TRAIL.
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Authors
Yi Zhang, Yan Cheng, Li Zhang, Xingcong Ren, Kathryn J Huber-Keener, Sang Lee, Jong Yun, Hong-Gang Wang, Jin-Ming Yang,