Glucose exposure pattern determines glucagon-like peptide 1 receptor expression and signaling through endoplasmic reticulum stress in rat insulinoma cells

Article ID	Journal	Published Year	Pages	File Type
10762794	Biochemical and Biophysical Research Communications	2011	6 Pages	PDF

Abstract

âº We study GLP-1 receptor expression and its consequences by glucose exposure pattern. âº Glucose fluctuation reduces GLP-1 receptor level more than chronic hyperglycemia. âº It induces more adverse ER stress and cytotoxicity in Î²-cells. âº GLP-1-induced calcium influx and insulin secretion are reduced by glucose fluctuation.

Keywords

GLP-1 GLP-1R sHG IHG ER stress Insulin secretion INS-1 cells endoplasmic reticulum glucagon-like peptide-1 GLP-1 receptor