Syntrophin isoforms play specific functional roles in the Î±1D-adrenergic receptor/DAPC signalosome

Article ID	Journal	Published Year	Pages	File Type
10762854	Biochemical and Biophysical Research Communications	2011	6 Pages	PDF

Abstract

âº The Î±1D-AR/DAPC signalosome is comprised of 3 syntrophin isoforms, Î±, Î²1 and Î²2. âº Î±-syntrophin selectively enhances Î±1D-AR binding site density in vitro. âº Î²2-syntrophin selectively enhances Î±1D-AR coupling to signal transduction pathways in vitro. âº Conclusion: syntrophin isoforms play distinct functional roles in the Î±1D-AR/DAPC signalosome.

Keywords

HEK ERK GPCR DAPC PDZ Signalosome Syntrophin G-protein coupled receptor adrenergic extracellular signal regulated kinase Pharmacology knock-out dystrophin-associated protein complex human embryonic kidney α1-Adrenergic receptor adrenergic receptor