| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762866 | Biochemical and Biophysical Research Communications | 2011 | 8 Pages |
Abstract
⺠Acidification of autophagosome was blunted in steatotic hepatocytes. ⺠Hepatic steatosis did not disturb fusion of isolated autophagosome and lysosome. ⺠Proteinase activity of cathepsin B and L in autolysosomes was inhibited by steatosis. ⺠Hepatic expression of cathepsin B and L was suppressed by steatosis.
Keywords
KRbNAFLDLysoTracker RedLTRLC3mTORGFPLAMP1Autophagynonalcoholic steatohepatitisKrebs–Ringer bicarbonate bufferNonalcoholic fatty liver diseaseanalysis of varianceANOVASteatosismicrotubule-associated protein light chain 3endoplasmic reticulumLysosomeNash mammalian target of rapamycinLysosomal-associated membrane protein 1green fluorescent proteinCathepsin
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Authors
Yoshihiro Inami, Shunhei Yamashina, Kousuke Izumi, Takashi Ueno, Isei Tanida, Kenichi Ikejima, Sumio Watanabe,