Article ID Journal Published Year Pages File Type
10762882 Biochemical and Biophysical Research Communications 2011 4 Pages PDF
Abstract
► Glucocorticoids upregulate REDD1 mRNA expression in skeletal muscle. ► The upregulation is robust, reproducible, and model independent. ► The upregulation is blocked by the glucocorticoid receptor antagonist RU-486. ► Upregulated REDD1 expression correlates with decreased mTORC1 signaling. ► Changes in REDD1 expression represent a surrogate biomarker for RU-486 effectiveness.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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REDD1 (regulated in development and DNA damage response 1) expression in skeletal muscle as a surrogate biomarker of the efficiency of glucocorticoid receptor blockade
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