| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762937 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Darunavir and tipranavir show higher drug-resistance barrier for HIV-1 protease. ⺠Darunavir preserves its potency by forming protease backbone hydrogen bonds. ⺠Tipranavir maintains its potency by stabilizing the protease flaps.
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Authors
Yong Wang, Zhigang Liu, Joseph S. Brunzelle, Iulia A. Kovari, Tamaria G. Dewdney, Samuel J. Reiter, Ladislau C. Kovari,