Article ID Journal Published Year Pages File Type
10762950 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► A novel chimeric promoter consisting of CArG element and hTERT promoter was developed. ► The promoter was characterized with radiation-inducibility and tumor-specificity. ► Suicide gene system driven by the promoter showed remarkable cytotoxicity in vitro. ► Co-expression of IL12 enhanced the promoter mediated suicide gene therapy in vivo.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Co-expression of interleukin 12 enhances antitumor effects of a novel chimeric promoter-mediated suicide gene therapy in an immunocompetent mouse model
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