| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762958 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠The nuclear enzyme PARP-1 is a downstream effector of oxidative stress. ⺠PARP-1 protects from oxidative stress induced endothelial dysfunction. ⺠This effect is mediated through inhibition of vasoconstrictor prostanoid production. ⺠Thus, PARP-1 may play a protective role as antioxidant defense mechanism.
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Authors
Cathérine Gebhard, Barbara E. Stähli, Yi Shi, Giovanni G. Camici, Alexander Akhmedov, Lisa Hoegger, Christine Lohmann, Christian M. Matter, Paul O. Hassa, Michael O. Hottiger, Tadeusz Malinski, Thomas F. Lüscher, Felix C. Tanner,