| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762964 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠β-Hydroxybutyrate inhibits insulin-mediated glucose uptake in oxidative muscle. ⺠We examined if AICAR, an activator of AMPK, reverses insulin resistance. ⺠AICAR restores most of the insulin effect on glucose uptake. ⺠AICAR exerts its positive effect on a late step in insulin signaling. ⺠Thus activation of AMPK reverses ketone-body mediated insulin resistance.
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Authors
Niklas Ivarsson, Shi-Jin Zhang, Abram Katz,