| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762965 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠To isolate miRNAs that regulate the response to interferon -α(IFN-α) in hepatoma. ⺠miRNA microarray analysis using parental PLC/PRF/5 and its IFN-α-resistant clones. ⺠miR-146a suppressed sensitivity to IFN-α through inhibition of apoptosis. ⺠The effect of miR-146a on sensitivity to IFN-α was mediated by SMAD4. ⺠Therapies targeting miR-146a/SMAD4 might be effective in hepatoma.
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Authors
Akira Tomokuni, Hidetoshi Eguchi, Yoshito Tomimaru, Hiroshi Wada, Koichi Kawamoto, Shogo Kobayashi, Shigeru Marubashi, Masahiro Tanemura, Hiroaki Nagano, Masaki Mori, Yuichiro Doki,