| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10762968 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠siRNA knockdown of OCT1 reduced sensitivity of EOC cells to metformin, but not to another biguanide, phenformin. ⺠Suppression of OCT1 also affects the activation of AMP kinase in response to metformin, but not to phenformin. ⺠Direct actions of metformin may be limited by low OCT1 expression in EOC tumors. ⺠Phenformin could be used as an alternative biguanide.
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Authors
Eric D. Segal, Amber Yasmeen, Marie-Claude Beauchamp, Joshua Rosenblatt, Michael Pollak, Walter H. Gotlieb,