Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer's disease model cell line

Article ID	Journal	Published Year	Pages	File Type
10762972	Biochemical and Biophysical Research Communications	2011	6 Pages	PDF

Abstract

âº Genome-wide DNA methylation pattern in Alzheimer's disease model cell line. âº Integrated analysis of CpG methylation and mRNA expression profiles. âº Identify three Swedish mutant target genes; CTIF, NXT2 and DDR2 gene. âº The effect of Swedish mutation on alteration of DNA methylation and gene expression.

Keywords

DDR Aβ qRT-PCR 5-Aza-dC DMS APP MSP BSP NBS 5-Aza-2′-deoxycytidine Methylation-specific PCR Bisulfite sequencing PCR Beta amyloid Alzheimer’s disease DNA methylation quantitative real-time polymerase chain reaction amyloid precursor protein Discoidin domain receptor